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The advantages of using corn steep liquor as a nitrogen source to produce erythromycin
Release time:
2024-08-14
Nitrogen source has long been considered an important parameter affecting enzyme expression and activity, and selecting appropriate organic nitrogen sources is crucial for erythromycin synthesis. Corn steep liquor is one of the widely used nitrogen sources in the antibiotic fermentation industry.
The market prospects of erythromycin are vast. It can not only be used as an antibiotic, but also as a precursor. Through a certain process, erythromycin can be converted into antibiotics such as erythromycin, azithromycin, clarithromycin, etc.
Nitrogen source has long been considered an important parameter affecting enzyme expression and activity, and selecting appropriate organic nitrogen sources is crucial for erythromycin synthesis. Corn steep liquor is one of the widely used nitrogen sources in the antibiotic fermentation industry.
1: Cheap price and rich nutrition
Compared with other fermentation substrates, corn steep liquid is only 1/5 cheaper than yeast extract and peptone, and can replace yeast extract as a nitrogen source for producing erythromycin; corn steep's nitrogen exists in the form of protein (43%) and amino acid (35%), which can serve as a quick acting nitrogen source and facilitate microbial utilization; It can serve as a source of trace elements such as phosphorus and magnesium, which are also essential catalysts in many metabolic pathways. It can also serve as a source of vitamins and other growth factors, which are essential for the production of many primary and secondary metabolites.
2: Can serve as a nitrogen source for the culture medium, promoting bacterial growth
Corn steep liquor is the most suitable organic nitrogen source for the industrial production of erythromycin. Adding corn steep water to the fermentation medium can increase the oxygen consumption rate of bacterial cells, promote microbial growth, reproduction, metabolism, and product synthesis; This is beneficial for the production of erythromycin.
Researchers have conducted experiments on seven fermentation media, and the results showed that using corn steeping as an organic nitrogen source, ammonium sulfate as an inorganic nitrogen source, and molasses as the sole carbon source in the media formula can achieve the highest erythromycin yield among the seven formulas; This is also the most suitable medium for producing erythromycin, and this medium formula based on inexpensive nitrogen and carbon sources is also a good choice for economically and efficiently producing erythromycin.
3: It can be used as nutritional supplement in fed-batch culture
The factors that affect the production of erythromycin and the growth of microbial cells include not only the ratio of carbon and nitrogen sources and the concentration of nitrogen, but also the form of nitrogen supplementation. fed-batch culture has been proven to effectively increase the yield of erythromycin.
Experimental results have shown that adding 0.2% isopropanol, 4% molasses, and 1% corn steep liquor as nutritional supplements during batch cultivation in a bioreactor can increase erythromycin production by 25% compared to batch cultivation without adding any nutrients.
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Specifically, when the culture medium contained 5 g/L Corn Steep Liquor Liquid and 7.6 g/L sodium glutamate, the absorbance of the red pigment reached 20.7 U, compared to only 12.4 U in the control. This indicates that the addition of Corn Steep Extract significantly increased red pigment production.
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