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Structure of cyclodextrin

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  • Time of issue:2021-09-16
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(Summary description)

Structure of cyclodextrin

(Summary description)

  • Categories:News
  • Author:
  • Origin:
  • Time of issue:2021-09-1649
  • Views:
Information

The cyclodextrin molecule has a slightly conical hollow cylindrical three-dimensional ring structure. In its hollow structure, the outer upper end (larger open end) is composed of secondary hydroxyl groups of C2 and C3, and the lower end (smaller open end) is composed of primary hydroxyl groups of C6, which is hydrophilic, while the hydrophobic region is formed in the cavity due to the shielding effect of C-H bond. There is neither reduction end nor non reduction end, and there is no reducibility; It is stable in alkaline medium, but it can be cracked by strong acid; Can only be α- Amylase can not be hydrolyzed β- Amylase hydrolysis, the tolerance to acid and general amylase is stronger than amylose; It can crystallize well in aqueous solution and alcohol aqueous solution; It has no fixed melting point and begins to decompose when heated to about 200 ℃. It has good thermal stability; No hygroscopicity, but easy to form various stable hydrates; Various organic compounds can be embedded in its hydrophobic cavity to form inclusion complexes and change the physical and chemical properties of the enveloped compounds; Many functional groups can be crosslinked on the cyclodextrin molecule, or cyclodextrin can be crosslinked on the polymer for chemical modification or polymerization with cyclodextrin as monomer.

 

Because the rim of cyclodextrin is hydrophilic and the cavity is hydrophobic, it can provide a hydrophobic binding site like an enzyme and envelope various appropriate guests as a host, such as organic molecules, inorganic ions and gas molecules. Because of its hydrophobic inner cavity and hydrophilic outer cavity, it can form inclusion complexes and molecular assembly systems with many organic and inorganic molecules according to van der Waals force, hydrophobic interaction force and the matching between host and guest molecules. It has become an interesting research object for chemical and chemical researchers. This selective envelope action, commonly known as molecular recognition, results in the formation of host guest complex. Cyclodextrin is an ideal host molecule similar to enzyme, and it has the characteristics of enzyme model. Therefore, cyclodextrin has been paid great attention and widely used in the fields of catalysis, separation, food and medicine. Due to the solubility and inclusion ability of cyclodextrins in water, changing the physical and chemical properties of cyclodextrins has become one of the important purposes of chemically modifying cyclodextrins.

Cyclodextrin complexes exist in nature and can also be synthesized. In industry, many dyes are based on cyclodextrin; Many medicinal plants with medical effects, such as aloe, contain cyclodextrin complexes. For example, the cyclodextrin complex in aloe gel can reduce inflammation, detumescence, relieve pain, relieve itching and inhibit the growth of bacteria. It can be used as a natural medicine for curing wounds. In addition, the cyclodextrin method using cyclodextrin is the best method to produce hydrogen peroxide.

Structure: multiple molecules α- 1,4-glycosidic bond end-to-end. It has a spiral structure in space.

α、β、γ- Cyclodextrin is a cyclic oligomer composed of 6, 7 and 8 d (+) - pyran glucose respectively. Its molecule is a cylindrical object with wide top and narrow bottom, open ends and hollow at both ends. The interior of the cavity is relatively hydrophobic, while all hydroxyl groups are outside the molecule.

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